Keitaro
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| This is actually awesome news for people and I'm really glad to hear they've been making great progress. Soon other diseases too will become much more manageable and even curable, I hope. |
FieryIce
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| Posted on 12-14-10 07:05:14 PM (last edited by FieryIce at 12-14-10 04:05 PM) |
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http://bloodjournal.hematologylibrary.org/cgi/content/abstract/blood-2010-09-309591v1
My boyfriend is reading the full article to understand the implications of this (he works for the NIH). It looks very promising, although, a stem cell transplant is a very extreme treatment ... but it's a huge step in the right direction, definitely!  |
Lyskar
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| Stats | Time/Date
12-14-10 01:07:51 PM
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| | Metal_Man88's Post | With how nasty that virus is, I find it hard to believe, but it seems likely they did find a way to cure it.
Unfortunately, that kind of transplant is really rare to get, so it doesn't sound like it'll be available to cure more HIV cases except in a few other lucky cases.
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Rick
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I agree, this is a wonderful first step that should hopefully lead to good things in the future.
I wonder when Magic Johnson is going to get this done. I mean, he's still rich enough, right? 
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Glisp
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I heard that too actually Terra.
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Rick
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It wouldn't surprise me. The common cold has the ability to change itself up so that there's no true "permanent" cure for it, so I don't see why that wouldn't apply to the AIDS virus itself.
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Xenesis
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Originally posted by Terra
Awesome!  Hopefully this will help the world in the fight against HIV. I remember learning about HIV in the 1990s in school, and they explained that the virus basically mutates itself very quickly so that antibodies won't get it. Or is that bunk? Could be bunk.
Definitely. HIV lacks the replication error-checking that most DNA/RNA replication methods employ in a huge proportion of life. Average mutation rate from replication alone in say, human mitosis is about 1 in 1x10^9 base pairs. HIV has a mutation rate of about 1 in 10,000.
This has the effect of producing a lot of dud mutations, but lets it adapt incredibly quickly to evolutionary pressures.
It is a pretty insidious virus in other ways too - Reverse transcription where it inserts it's own genome into the host cell's permanently means that as long as that cell lives it has the potential to produce more HIV, even if it lies dormant for years.
The other of course being that it attacks human T-Cells. The way the body deals with most cellular viral infections is to kill the cell that is infected. So, it kills your immunodefences. Hence, AIDS.
But the fact that they've managed to suppress it in what appears to be a mostly permanent fashion is rather amazing. Whether it'll hold is another matter entirely. |
