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05-21-18 03:41:23 AM

Jul - News - C60 suspension in olive oil almost doubles mice lifespan New poll - New thread - New reply
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Kironide_
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Posted on 08-04-13 08:41:33 PM (last edited by Kironide_ at 08-04-13 08:41:54 PM) Link | Quote
http://www.sciencedirect.com/science/article/pii/S0142961212003237 - thoughts?
PDF at: https://dl.dropboxusercontent.com/u/10369745/c60oo.pdf
Criticism at: http://www.longecity.org/forum/page/index.html/_/articles/c60health

Countless studies showed that [60]fullerene (C60) and derivatives could have many potential biomedical
applications. However, while several independent research groups showed that C60 has no acute or subacute toxicity in various experimental models, more than 25 years after its discovery the in vivo fate and
the chronic effects of this fullerene remain unknown. If the potential of C60 and derivatives in the
biomedical field have to be fulfilled these issues must be addressed. Here we show that oral administration of C60 dissolved in olive oil (0.8 mg/ml) at reiterated doses (1.7 mg/kg of body weight) to rats not
only does not entail chronic toxicity but it almost doubles their lifespan. The effects of C60-olive oil
solutions in an experimental model of CCl4 intoxication in rat strongly suggest that the effect on lifespan
is mainly due to the attenuation of age-associated increases in oxidative stress.
Pharmacokinetic studies
show that dissolved C60 is absorbed by the gastro-intestinal tract and eliminated in a few tens of hours.
These results of importance in the fields of medicine and toxicology should open the way for the many
possible -and waited for- biomedical applications of C60 including cancer therapy, neurodegenerative
disorders, and ageing.
Peardian

  
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Posted on 08-04-13 09:18:24 PM Link | Quote
If this proves to be true, it's quite fascinating. Of course, it won't be long before obnoxious advertisers start trying to market it as the next wonder drug to reverse ageing and such.
Xenesis
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Posted on 08-04-13 09:45:34 PM Link | Quote
That is cool, but an enormous dose required.

Kironide_
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Posted on 08-04-13 10:20:57 PM Link | Quote
Originally posted by Xenesis
That is cool, but an enormous dose required.




Well it's not _that_ big - 1.7 mg/kg for me is under under 80 mg, but I take 100mg zinc nightly.
2Tie

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Posted on 08-06-13 01:15:25 AM Link | Quote
To be honest, I would never want to take something made to prolong one's life... It just seems like it would be detrimental to humans as a whole, I mean, we're already growing quite populous already...
That's mostly why I refuse to take any medicine for anything :/ If my body can get through something unassisted, why should I feed it unnatural supplements...
Gah, my ramblings, apologies. Interesting find, yes. Just not sure how happy I am with it...
Xenesis
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Posted on 08-06-13 03:33:42 AM Link | Quote
Originally posted by Kironide_
Originally posted by Xenesis
That is cool, but an enormous dose required.




Well it's not _that_ big - 1.7 mg/kg for me is under under 80 mg, but I take 100mg zinc nightly.


It'd more be the suspension of olive oil - Do you really want to have to drink ~100 mL of olive oil regularly? That has more potential issues, unless they find a way to create that suspension by other means.
Lyskar
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Posted on 08-08-13 06:24:24 PM Link | Quote
Everything ever doubles mice lifespan, but mice are not as complex as humans, not as long lived, and you can robotically control their entire life.

So...

Much like the latest "BATTERY POWER DOUBLED", doesn't really amount to meaning much. :\
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Jul - News - C60 suspension in olive oil almost doubles mice lifespan New poll - New thread - New reply




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